Dendritic cells (DCs) are key players in the induction and re elicitation of T helper (Th) 2 immune responses to allergens. Recent data by our group have shown that different C type lectin receptors (CLRs) on DCs play a major role in allergen recognition and uptake. Particularly, mannose receptor (MR), through modulation of Toll like receptor (TLR) 4 signalling pathway steroids, can regulate indoleamine 2,3 dioxygenase (IDO) activity favouring Th2 responses.
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